A Longitudinal Study of Brain Volume Changes in Normal Aging Using Serial Registered Magnetic Resonance Imaging

نویسندگان

  • Rachael I. Scahill
  • Rhian Jenkins
  • Jennifer L. Whitwell
  • Martin N. Rossor
چکیده

Results: We found significant decreases in crosssectional whole-brain (P .001), temporal lobe (P .001), and hippocampal (P=.003) volumes and a significant increase in ventricular volume (P .001) with increasing age. Cross-sectional and longitudinal estimates of atrophy rates were similar. We also found directional evidence of acceleration in atrophy rates with increasing age in all analyses, with the most marked changes occurring after 70 years of age. This increase in rates after 70 years of age was particularly marked in the ventricles (P .001) and the hippocampi (P=.01).

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تاریخ انتشار 2003